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BACKGROUND
Chronic denervation is one of the harmful consequences of long regeneration times and distance that profoundly inhibits functional recovery following nerve injuries. Surgical strategies that demonstrate the ability to protect against chronic denervation may do so by supplementing the growth supportive, neurotrophic environment within...
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BACKGROUND
In recent years, directed differentiation of pluripotent stem cells (PSCs) has become a major focus of regenerative medicine to help address the shortcomings of pulmonary therapeutics or transplantation. Specific efforts have focused on endoderm-derived lung epithelium tissue regeneration, while mesoderm-derived tissues in the lungs,...
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BACKGROUND
Glioblastoma (GBM) is the most common and aggressive brain cancer, and accounts for 60% of adult brain tumours. The median survival of adult GBM patients is 15 months, where the standard-of-care is a combination of surgery, radiation, and chemotherapy using the DNA alkylating agent temozolomide (TMZ), which extends patient survival by...
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Clostridium difficile (C. difficile), a spore forming bacteria, is the leading cause of hospital acquired diarrhea and antibiotic associated pseudomembranous colitis. Disruption of the protective gut microbiota by antibiotics creates a niche and enables colonization of opportunistic multidrug resistant C. difficile. Once colonized, C....
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BACKGROUND
Genetic expansions of CAG/CTG trinucleotide repeat sequences in certain genes have been linked to at least 40 neurodegenerative, neurological, and neuromuscular diseases, including Huntington's disease (HD), fragile X syndrome, myotonic dystrophy, various spinocerebellar ataxias, and amyotrophic lateral sclerosis. These repeat expansions...
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BACKGROUND
Clostridium difficile (C. difficile), a spore-forming bacteria, is the leading cause of hospital acquired diarrhea and antibiotic associated pseudomembranous colitis. Disruption of the protective gut microbiota by antibiotics enables colonization by multidrug resistant C. difficile, which secrete up to three different protein toxins that...
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BACKGROUND
Helicobacter pylori (H. pylori) infects the stomach of half of the world’s population. Infection causes peptic ulcer disease, is associated with functional dyspepsia and is recognized by the World Health Organization (WHO) as a carcinogen that causes gastric cancer; the third leading cause of cancer-related deaths worldwide. As...
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BACKGROUND
Cystic Fibrosis (CF) is a chronic multi-organ disease that affects between 70,000 - 100,000 people worldwide. The symptoms of the disease include chronic respiratory infections, pancreatic insufficiency, and gastrointestinal disease. The disease is caused by loss-of-function mutations in the Cystic Fibrosis transmembrane conductance regulator...
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BACKGROUND
Medulloblastoma is the most common malignant pediatric brain tumor consisting of at least four distinct molecular sub-groups: Wingless (WNT), sonic hedgehog (SHH), Group 3 and Group 4. These subgroups are characterized by divergent genetic aberrations, cytogenic features, and distinct phenotypes including patient demographics and clinical...
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BACKGROUND
There are many challenges to improving peripheral nerve regeneration and functional outcomes following injury. Peripheral nerve injuries can be severely debilitating, affecting otherwise healthy patients by permanently limiting their ability to perform activities of daily living. Currently, there are no therapeutic interventions available...
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