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Search Results - tcdb

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Gut-restricted bile acid therapeutics to treat Clostridium difficile
BACKGROUND Clostridium difficile (C. difficile), a spore forming bacteria, is the leading cause of hospital acquired diarrhea and antibiotic associated pseudomembranous colitis. Disruption of the protective gut microbiota by antibiotics creates a niche and enables colonization of opportunistic multidrug resistant C. difficile. Once colonized, C....
Inventor(s): Roman Melnyk
Categories: Technology Classifications > Therapeutics
Keyword(s): bile acid, Clostridium difficile, TcdB
Niclosamide Inhibits Clostridium Difficile Toxin Pathogenesis
BACKGROUND Clostridium difficile (C. difficile), a spore-forming bacteria, is the leading cause of hospital acquired diarrhea and antibiotic associated pseudomembranous colitis. Disruption of the protective gut microbiota by antibiotics enables colonization by multidrug resistant C. difficile, which secrete up to three different protein toxins that...
Inventor(s): Roman Melnyk
Categories: Technology Classifications > Therapeutics
Keyword(s): Clostridium difficile, niclosamide, TcdA, TcdB