Search Results - technology+classifications+%3e+platform+technologies

3 Results

Sort By:

BACKGROUND Myeloproliferative neoplasms such as acute myeloid leukemia (AML) are cancers of the bone marrow and blood. Incidence of AML range from 3–8 cases per 100,000 globally, predominantly in United States and Japan. Standard of care therapies include chemotherapy and allogeneic stem cell transplantation to help prolong remission. However,...

Inventor(s): Jane McGlade

Categories: Technology Classifications > Platform Technologies

Keyword(s): AML, cancer, drug discovery, leukemia, myeloproliferative neoplasms, small molecule therapeutics

AtriumDB: An integrated AI/ML-based robust platform to store and interrogate massive waveform data

BACKGROUND Waveform data from physiologic monitoring devices is the most informative data from a patient. This includes waveforms produced by monitoring mechanical pressures in arteries (arterial blood pressure), electrocardiograms, electroencephalograms and oxygen saturation (Fig 1). Real time storage and access of that data for secondary uses...

Inventor(s): Andrew Goodwin, Peter Laussen, Robert Greer, Anirudh Thommandram, Mijaye Mazwi

Categories: Technology Classifications > Clinical Tools, Technology Classifications > IT/Software, Technology Classifications > Platform Technologies

Keyword(s): indexing, physiology, waveform

Gene editing system for correcting splicing defects

BACKGROUND According to recent estimates, splice site defects account for 5% to 10% of pathogenic mutations causing Mendelian diseases. The prevalence is even higher for neuromuscular disorders (NMDs) due to the unusually large size and the multi-exonic structure of genes encoding muscle structural proteins, further highlighting the importance of...

Inventor(s): Ronald Cohn, Evgueni Ivakine, Dwi Kemaladewi

Categories: Technology Classifications > Platform Technologies

Keyword(s): gene editing, muscular dystrophy, NHEJ, splicing defect