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Search Results - drug+discovery

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CBL Targeted Therapeutics
BACKGROUND Myeloproliferative neoplasms such as acute myeloid leukemia (AML) are cancers of the bone marrow and blood. Incidence of AML range from 3–8 cases per 100,000 globally, predominantly in United States and Japan. Standard of care therapies include chemotherapy and allogeneic stem cell transplantation to help prolong remission. However,...
Inventor(s): Jane McGlade
Categories: Technology Classifications > Platform Technologies
Keyword(s): AML, cancer, drug discovery, leukemia, myeloproliferative neoplasms, small molecule therapeutics
MATCH: A Novel Machine Learning-Based Assay Platform to Determine Drug Cardiotoxicity
BACKGROUND Unpredicted cardiotoxicity and cardiovascular safety concerns are responsible for the termination of nearly one-third of all compounds in drug discovery pipelines. These unforeseen adverse effects add significant cost and time to therapeutic discovery and expose patients to an unneeded risk of harm. Current in vitro and in vivo preclinical...
Inventor(s): Jason Maynes
Categories: MedTech, Technology Classifications > Medical Devices
Keyword(s): artificial intelligence, cardiac, drug discovery, machine learning, platform, toxicity