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BACKGROUND Clubfoot is the most common congenital orthopaedic anomaly occurring in 1 in 1,000 live births. The affected foot is in an excessive down-and-in position (equinovarus) with a high medial arch (cavus). Without treatment, clubfoot can result in long-term disability and pain. Standard of care for treatment of clubfoot is the Ponseti method,...
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BACKGROUND Unpredicted cardiotoxicity and cardiovascular safety concerns are responsible for the termination of nearly one-third of all compounds in drug discovery pipelines. These unforeseen adverse effects add significant cost and time to therapeutic discovery and expose patients to an unneeded risk of harm. Current in vitro and in vivo preclinical...
Inventor(s): Jason Maynes
BACKGROUND Acute Respiratory Distress Syndrome (ARDS) is a type of respiratory failure seen in severe cases of COVID-19 and Pneumonia. It is characterized by the lungs being inflamed, waterlogged and the lower lung being closed. One current solution to opening the lower lung is ventilating with relatively high enough pressure to inflate the lower...
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