<?xml version="1.0" encoding="utf-8"?><rss version="2.0"><channel><title>Latest technologies from The Hospital for Sick Children</title><link>http://sickkids.technologypublisher.com</link><description>Be the first to know about the latest inventions and technologies available from The Hospital for Sick Children</description><language>en-US</language><pubDate>Sat, 16 May 2026 03:13:37 GMT</pubDate><lastBuildDate>Fri, 02 Jun 2023 13:24:59 GMT</lastBuildDate><docs>http://blogs.law.harvard.edu/tech/rss</docs><webMaster>anny.song@sickkids.ca</webMaster><copyright>Copyright 2026, The Hospital for Sick Children</copyright><item><title>ErbB2 Signalling for Nerve Regeneration</title><caseId>RDLP 904</caseId><link>https://sickkids.technologypublisher.com/tech/ErbB2_Signalling_for_Nerve_Regeneration</link><description><![CDATA[
	
		
			
			&nbsp;

			BACKGROUND

			Chronic denervation is one of the harmful consequences of long regeneration times and distance that profoundly inhibits functional recovery following nerve injuries. Surgical strategies that demonstrate the ability to protect against chronic denervation may do so by supplementing the growth supportive, neurotrophic environment within the denervated nerve stump. The Schwann cell response to injury is a critical event following peripheral nerve injury because it contributes to generating an environment conducive to axonal regeneration. A family of growth fa...]]></description><pubDate>Fri, 02 Jun 2023 13:24:59 GMT</pubDate><author>anny.song@sickkids.ca</author><guid>https://sickkids.technologypublisher.com/tech/ErbB2_Signalling_for_Nerve_Regeneration</guid></item><item><title>CBL Targeted Therapeutics</title><caseId>RDLP 1105</caseId><link>https://sickkids.technologypublisher.com/tech/CBL_Targeted_Therapeutics</link><description><![CDATA[
	
		
			
			&nbsp;

			BACKGROUND

			Myeloproliferative neoplasms such as acute myeloid leukemia (AML) are cancers of the bone marrow and blood. Incidence of AML range from 3&ndash;8 cases per 100,000 globally, predominantly in United States and Japan. Standard of care therapies include chemotherapy and allogeneic stem cell transplantation to help prolong remission. However, the discovery of novel molecular profiles in AML has now defined several subsets with differing prognosis and a suite of targeted therapeutics. Despite these advances in understanding the genetic heterogeneity of AML and...]]></description><pubDate>Fri, 02 Jun 2023 13:24:53 GMT</pubDate><author>anny.song@sickkids.ca</author><guid>https://sickkids.technologypublisher.com/tech/CBL_Targeted_Therapeutics</guid></item><item><title>AtriumDB: An integrated AI/ML-based robust platform to store and interrogate massive waveform data</title><caseId>RDLP 1103</caseId><link>https://sickkids.technologypublisher.com/tech?title=AtriumDB%3a_An_integrated_AI%2fML-based_robust_platform_to_store_and_interrogate_massive_waveform_data</link><description><![CDATA[
	
		
			
			BACKGROUND
			Waveform data from physiologic monitoring devices is the most informative data from a patient. This includes waveforms produced by monitoring mechanical pressures in arteries (arterial blood pressure), electrocardiograms, electroencephalograms and oxygen saturation (Fig 1).&nbsp;

			Real time storage and access of that data for secondary uses (i.e. retrospective studies and Machine Learning), is cost-prohibitive. The lack of access to waveform data sources is a major barrier to clinical decision support, quality improvement and actionable information for translation...]]></description><pubDate>Fri, 02 Jun 2023 13:24:48 GMT</pubDate><author>anny.song@sickkids.ca</author><guid>https://sickkids.technologypublisher.com/tech?title=AtriumDB%3a_An_integrated_AI%2fML-based_robust_platform_to_store_and_interrogate_massive_waveform_data</guid></item><item><title>Engineered macrophage cell therapy for lung cancer, infections and other lung diseases</title><caseId>TECH 1389</caseId><link>https://sickkids.technologypublisher.com/tech?title=Engineered_macrophage_cell_therapy_for_lung_cancer%2c_infections_and_other_lung_diseases</link><description><![CDATA[&nbsp;


	
		
			
			BACKGROUND

			In recent years, directed differentiation of pluripotent stem cells (PSCs) has become a major focus of regenerative medicine to help address the shortcomings of pulmonary therapeutics or transplantation. Specific efforts have focused on endoderm-derived lung epithelium tissue regeneration, while mesoderm-derived tissues in the lungs, such as non-circulating hematopoietic lineages, have received minimal attention. This oversight in pulmonary stem cell regenerative medicine has led to a failure in appropriately addressing the importance of the innate immune sy...]]></description><pubDate>Fri, 02 Jun 2023 13:20:32 GMT</pubDate><author>anny.song@sickkids.ca</author><guid>https://sickkids.technologypublisher.com/tech?title=Engineered_macrophage_cell_therapy_for_lung_cancer%2c_infections_and_other_lung_diseases</guid></item><item><title>Automated Pain Behavior Testing in Mice</title><caseId>TECH 1369</caseId><link>https://sickkids.technologypublisher.com/tech/Automated_Pain_Behavior_Testing_in_Mice</link><description><![CDATA[
	
		
			
			&nbsp;

			PROBLEM

			Measuring reflexive withdrawal to noxious stimulation in laboratory rodents is a mainstay of preclinical pain research. Testing is typically conducted on the hind paw. Most chronic pain models are designed to increase paw sensitivity through manipulations of the paw or of the nerves innervating the paw. Potential analgesics are tested for their ability to reverse that hypersensitivity. Notwithstanding caveats about inferring human pain perception from changes in rodent withdrawal reflexes, rodent pain models and the associated assessment of paw sensitivity c...]]></description><pubDate>Fri, 02 Jun 2023 13:20:01 GMT</pubDate><author>anny.song@sickkids.ca</author><guid>https://sickkids.technologypublisher.com/tech/Automated_Pain_Behavior_Testing_in_Mice</guid></item><item><title>Treating primary brain cancer using an ion channel complex-targeting peptide</title><caseId>TECH 1358</caseId><link>https://sickkids.technologypublisher.com/tech/Treating_primary_brain_cancer_using_an_ion_channel_complex-targeting_peptide</link><description><![CDATA[
	
		
			
			&nbsp;

			BACKGROUND

			Glioblastoma (GBM) is the most common and aggressive brain cancer, and accounts for 60% of adult brain tumours. The median survival of adult GBM patients is 15 months, where the standard-of-care is a combination of surgery, radiation, and chemotherapy using the DNA alkylating agent temozolomide (TMZ), which extends patient survival by approximately two months.

			However, TMZ is not cancer cell specific, resulting in neural, hematological, and gastrointestinal toxicities. 50% of patients do not respond to TMZ due to the tumour&rsquo;s heterogeneity. More...]]></description><pubDate>Fri, 02 Jun 2023 13:19:42 GMT</pubDate><author>anny.song@sickkids.ca</author><guid>https://sickkids.technologypublisher.com/tech/Treating_primary_brain_cancer_using_an_ion_channel_complex-targeting_peptide</guid></item><item><title>Dynamic Foot Abduction Bar</title><caseId>TECH 1355</caseId><link>https://sickkids.technologypublisher.com/tech/Dynamic_Foot_Abduction_Bar</link><description><![CDATA[
	
		
			
			&nbsp;

			BACKGROUND

			Clubfoot is the most common congenital orthopaedic anomaly occurring in 1 in 1,000 live births. The affected foot is in an excessive down-and-in position (equinovarus) with a high medial arch (cavus). Without treatment, clubfoot can result in long-term disability and pain. Standard of care for treatment of clubfoot is the Ponseti method, which consists of serial manipulation and casting, and a percutaneous Achilles tenotomy to correct the foot shape. The correction is then maintained using a Foot Abduction Brace (FAB). The wear schedule for the FAB is 23 ...]]></description><pubDate>Fri, 02 Jun 2023 13:19:36 GMT</pubDate><author>anny.song@sickkids.ca</author><guid>https://sickkids.technologypublisher.com/tech/Dynamic_Foot_Abduction_Bar</guid></item><item><title>Gut-restricted bile acid therapeutics to treat Clostridium difficile</title><caseId>TECH 1427</caseId><link>https://sickkids.technologypublisher.com/tech/Gut-restricted_bile_acid_therapeutics_to_treat_Clostridium_difficile</link><description><![CDATA[
	
		
			
			&nbsp;

			BACKGROUND

			Clostridium difficile (C. difficile), a spore forming bacteria, is the leading cause of hospital acquired diarrhea and antibiotic associated pseudomembranous colitis. Disruption of the protective gut microbiota by antibiotics creates a niche and enables colonization of opportunistic multidrug resistant C. difficile. Once colonized, C. difficile releases a highly potent toxin&ndash;TcdB&ndash;that destroys the colonic epithelial barrier, leading to watery diarrhea, fever, nausea, and abdominal pain. In the United States alone, C. difficile affects 500,000 ...]]></description><pubDate>Fri, 02 Jun 2023 13:19:14 GMT</pubDate><author>anny.song@sickkids.ca</author><guid>https://sickkids.technologypublisher.com/tech/Gut-restricted_bile_acid_therapeutics_to_treat_Clostridium_difficile</guid></item><item><title>Clinical development of minimally invasive tools for cancer detection and monitoring</title><caseId>RDLP 1321</caseId><link>https://sickkids.technologypublisher.com/tech/Clinical_development_of_minimally_invasive_tools_for_cancer_detection_and_monitoring</link><description><![CDATA[
	
		
			
			&nbsp;

			BACKGROUND

			Brain tumours are currently the leading cause of childhood cancer death. The last decade has seen a massive growth in our understanding of brain tumour genetics including the discovery of diagnostic, prognostic, and therapeutic markers. Currently, molecular characterization of these tumours requires a biopsy, which is invasive and risky, particularly in the brain. We can remove this risk to patients by using &ldquo;liquid biopsies&rdquo;, taking advantage of the discovery that fluids like blood and cerebral spinal fluid carry small amounts of tumour DNA (...]]></description><pubDate>Fri, 02 Jun 2023 13:17:41 GMT</pubDate><author>anny.song@sickkids.ca</author><guid>https://sickkids.technologypublisher.com/tech/Clinical_development_of_minimally_invasive_tools_for_cancer_detection_and_monitoring</guid></item><item><title>ML-based RNA analysis for cancer diagnosis, prognosis, and therapy guidance applications</title><caseId>RDLP 1278</caseId><link>https://sickkids.technologypublisher.com/tech?title=ML-based_RNA_analysis_for_cancer_diagnosis%2c_prognosis%2c_and_therapy_guidance_applications</link><description><![CDATA[
	
		
			
			&nbsp;

			BACKGROUND

			Cancer is the second leading cause of death globally, accounting for nearly 10 million deaths and billions of dollars in healthcare expense. Accurate and early diagnosis of cancer is critical to determine precision treatment plans, improve patient outcomes, decrease morbidity, and decrease the financial burden of cancer.&nbsp;

			DNA sequencing has been implemented in personalized oncology, but this is not reflective of the tumor&rsquo;s ongoing expression program or the active pathology of the disease. RNA-Seq methods can inform about the active express...]]></description><pubDate>Fri, 02 Jun 2023 13:16:40 GMT</pubDate><author>anny.song@sickkids.ca</author><guid>https://sickkids.technologypublisher.com/tech?title=ML-based_RNA_analysis_for_cancer_diagnosis%2c_prognosis%2c_and_therapy_guidance_applications</guid></item><item><title>Highly sensitive diagnostic tests for Brugada Syndrome (BrS)</title><caseId>RDLP 1238</caseId><link>https://sickkids.technologypublisher.com/tech/Highly_sensitive_diagnostic_tests_for_Brugada_Syndrome_(BrS)</link><description><![CDATA[
	
		
			
			&nbsp;

			BACKGROUND

			Sudden cardiac arrest (SCA) is the abrupt loss of heart function, breathing, and consciousness. SCA is usually caused by an electrical disturbance in the heart, which disrupts heart pumping and consequently the blood flow. In the case of a defect in electrical impulses or in the sinus node, SCA can lead to abnormal heart rhythm or arrhythmia. If not treated immediately, SCA can lead to Sudden Cardiac Death (SCD), which is the second largest cause of life-years lost in the US. Some SCD disorders are difficult to diagnose, such as Brugada Syndrome (BrS).&nb...]]></description><pubDate>Fri, 02 Jun 2023 13:15:46 GMT</pubDate><author>anny.song@sickkids.ca</author><guid>https://sickkids.technologypublisher.com/tech/Highly_sensitive_diagnostic_tests_for_Brugada_Syndrome_(BrS)</guid></item><item><title>Gene editing system for correcting splicing defects</title><caseId>RDLP 1170</caseId><link>https://sickkids.technologypublisher.com/tech/Gene_editing_system_for_correcting_splicing_defects</link><description><![CDATA[
	
		
			
			&nbsp;

			BACKGROUND

			According to recent estimates, splice site defects account for 5% to 10% of pathogenic mutations causing Mendelian diseases. The prevalence is even higher for neuromuscular disorders (NMDs) due to the unusually large size and the multi-exonic structure of genes encoding muscle structural proteins, further highlighting the importance of these mutations in NMDs. Therapeutic genome editing can be exploited to correct disease-causing mutations. However, in previous studies, correction of splice site mutations have only been accomplished via the homology-direc...]]></description><pubDate>Fri, 02 Jun 2023 13:14:18 GMT</pubDate><author>anny.song@sickkids.ca</author><guid>https://sickkids.technologypublisher.com/tech/Gene_editing_system_for_correcting_splicing_defects</guid></item><item><title>Highly sensitive diagnostic test for arrhythmogenic right ventricular cardiomyopathy (ARVC)</title><caseId>RDLP 1138</caseId><link>https://sickkids.technologypublisher.com/tech/Highly_sensitive_diagnostic_test_for_arrhythmogenic_right_ventricular_cardiomyopathy_(ARVC)</link><description><![CDATA[
	
		
			
			&nbsp;

			BACKGROUND

			Sudden cardiac arrest (SCA) is the abrupt loss of heart function, breathing, and consciousness. SCA is usually caused by an electrical disturbance in the heart, which disrupts heart pumping and consequently the blood flow. In the case of a defect in electrical impulses or in the sinus node, SCA can lead to abnormal heart rhythm or arrhythmia. If not treated immediately, SCA can lead to Sudden Cardiac Death (SCD), which is the second largest cause of life-years lost in the US. Some SCD disorders are difficult to diagnose, including Arrhythmogenic Right Ven...]]></description><pubDate>Fri, 02 Jun 2023 13:13:32 GMT</pubDate><author>anny.song@sickkids.ca</author><guid>https://sickkids.technologypublisher.com/tech/Highly_sensitive_diagnostic_test_for_arrhythmogenic_right_ventricular_cardiomyopathy_(ARVC)</guid></item><item><title>Novel therapeutic modality to treat trinucleotide repeat expansion diseases</title><caseId>RDLP 1123</caseId><link>https://sickkids.technologypublisher.com/tech/Novel_therapeutic_modality_to_treat_trinucleotide_repeat_expansion_diseases</link><description><![CDATA[
	
		
			
			&nbsp;

			BACKGROUND

			Genetic expansions of CAG/CTG trinucleotide repeat sequences&nbsp;in certain genes have been linked to at least 40&nbsp;neurodegenerative, neurological, and neuromuscular&nbsp;diseases,&nbsp;including Huntington&#39;s disease (HD), fragile X syndrome,&nbsp;myotonic dystrophy, various spinocerebellar ataxias, and&nbsp;amyotrophic lateral sclerosis. These&nbsp;repeat expansions tend to&nbsp;get larger as they are inherited from one generation to the next,&nbsp;resulting in earlier age of onset, increased disease progression&nbsp;and severity.&nbsp;Important...]]></description><pubDate>Fri, 02 Jun 2023 13:13:15 GMT</pubDate><author>anny.song@sickkids.ca</author><guid>https://sickkids.technologypublisher.com/tech/Novel_therapeutic_modality_to_treat_trinucleotide_repeat_expansion_diseases</guid></item><item><title>MATCH: A Novel Machine Learning-Based Assay Platform to Determine Drug Cardiotoxicity</title><caseId>RDLP 1071</caseId><link>https://sickkids.technologypublisher.com/tech?title=MATCH%3a_A_Novel_Machine_Learning-Based_Assay_Platform_to_Determine_Drug_Cardiotoxicity</link><description><![CDATA[
	
		
			
			&nbsp;

			BACKGROUND

			Unpredicted cardiotoxicity and cardiovascular safety concerns are responsible for the termination of nearly one-third of all compounds in drug discovery pipelines. These unforeseen adverse effects add significant cost and time&nbsp;to therapeutic discovery and expose patients to an unneeded risk of harm.

			Current in vitro and in vivo preclinical models of cardiac function inadequately predict how a drug candidate will affect cardiac activity or induce toxicity. Elimination of compounds with potential cardiotoxicity earlier in the drug discovery continu...]]></description><pubDate>Fri, 02 Jun 2023 13:12:08 GMT</pubDate><author>anny.song@sickkids.ca</author><guid>https://sickkids.technologypublisher.com/tech?title=MATCH%3a_A_Novel_Machine_Learning-Based_Assay_Platform_to_Determine_Drug_Cardiotoxicity</guid></item><item><title>Continuous Negative Abdominal Pressure (CNAP) device</title><caseId>RDLP 1058</caseId><link>https://sickkids.technologypublisher.com/tech/Continuous_Negative_Abdominal_Pressure_(CNAP)_device</link><description><![CDATA[
	
		
			
			&nbsp;

			BACKGROUND

			Acute Respiratory Distress Syndrome (ARDS) is a type of respiratory failure seen in severe cases of COVID-19 and Pneumonia. It is characterized by the lungs being inflamed, waterlogged and the lower lung being closed. One current solution to opening the lower lung is ventilating with relatively high enough pressure to inflate the lower lung. Another current solution involves flipping the patient onto their stomach while ventilating. While on their stomach gravity pulls down the diaphragm, allowing more room for the lower lung to inflate. The disadvantages...]]></description><pubDate>Fri, 02 Jun 2023 13:11:55 GMT</pubDate><author>anny.song@sickkids.ca</author><guid>https://sickkids.technologypublisher.com/tech/Continuous_Negative_Abdominal_Pressure_(CNAP)_device</guid></item><item><title>Niclosamide Inhibits Clostridium Difficile Toxin Pathogenesis</title><caseId>RDLP 1045</caseId><link>https://sickkids.technologypublisher.com/tech/Niclosamide_Inhibits_Clostridium_Difficile_Toxin_Pathogenesis</link><description><![CDATA[
	
		
			
			&nbsp;

			BACKGROUND

			Clostridium difficile (C. difficile), a spore-forming bacteria, is the leading cause of hospital acquired diarrhea and antibiotic associated pseudomembranous colitis. Disruption of the protective gut microbiota by antibiotics enables colonization by multidrug resistant C. difficile, which secrete up to three different protein toxins that are&nbsp;responsible for the gastrointestinal sequelae. Infections resulting from C. difficile present a significant health burden, costing upwards of $4.5 billion. Disease symptoms associated with infection arise from th...]]></description><pubDate>Fri, 02 Jun 2023 13:11:40 GMT</pubDate><author>anny.song@sickkids.ca</author><guid>https://sickkids.technologypublisher.com/tech/Niclosamide_Inhibits_Clostridium_Difficile_Toxin_Pathogenesis</guid></item><item><title>A novel small molecule for treatment of Helicobacter pylori infection</title><caseId>RDLP 1013</caseId><link>https://sickkids.technologypublisher.com/tech/A_novel_small_molecule_for_treatment_of_Helicobacter_pylori_infection</link><description><![CDATA[
	
		
			
			&nbsp;

			BACKGROUND

			Helicobacter pylori (H. pylori) infects the stomach of half of the world&rsquo;s population. Infection causes peptic ulcer disease, is associated with functional dyspepsia and is recognized by the World Health Organization (WHO) as a carcinogen that causes gastric cancer; the third leading cause of cancer-related deaths worldwide. As eradication of H. pylori reduces gastric cancer, the WHO has called for H. pylori screening and treatment programs to reduce cancer risk.

			The current treatment for H. pylori uses a combination of antibiotics and proton pu...]]></description><pubDate>Fri, 02 Jun 2023 13:11:10 GMT</pubDate><author>anny.song@sickkids.ca</author><guid>https://sickkids.technologypublisher.com/tech/A_novel_small_molecule_for_treatment_of_Helicobacter_pylori_infection</guid></item><item><title>Novel Treatments for Cystic Fibrosis: Moving beyond CFTR modulators</title><caseId>RDLP 995</caseId><link>https://sickkids.technologypublisher.com/tech?title=Novel_Treatments_for_Cystic_Fibrosis%3a_Moving_beyond_CFTR_modulators</link><description>
	
		
			
			BACKGROUND

			Cystic Fibrosis (CF) is a chronic multi-organ disease that affects between 70,000 - 100,000 people worldwide. The symptoms of the disease include chronic respiratory infections, pancreatic insufficiency, and gastrointestinal disease. The disease is caused by loss-of-function mutations in the Cystic Fibrosis transmembrane conductance regulator (CFTR) which is an ABC transporter-class ion channel protein that conducts chloride ions across epithelial cell membranes in vertebrates. This loss-of- function presents significant morbidity for individuals with CF.

			Health...</description><pubDate>Fri, 02 Jun 2023 13:10:53 GMT</pubDate><author>anny.song@sickkids.ca</author><guid>https://sickkids.technologypublisher.com/tech?title=Novel_Treatments_for_Cystic_Fibrosis%3a_Moving_beyond_CFTR_modulators</guid></item><item><title>Method of Treating Medulloblastoma</title><caseId>RDLP 994</caseId><link>https://sickkids.technologypublisher.com/tech/Method_of_Treating_Medulloblastoma</link><description>
	
		
			
			BACKGROUND

			Medulloblastoma is the most common malignant pediatric brain tumor consisting of at least four distinct molecular sub-groups: Wingless (WNT), sonic hedgehog (SHH), Group 3 and Group 4. These subgroups are characterized by divergent genetic aberrations, cytogenic features, and distinct phenotypes including patient demographics and clinical outcome.
			Tumors with WNT pathway activation have the most favourable prognosis whereas Group 3 medulloblastomas have the worst outcome. Group 3 tumors are restricted to pediatrics patients, characterized by the amplification of ...</description><pubDate>Fri, 02 Jun 2023 13:10:50 GMT</pubDate><author>anny.song@sickkids.ca</author><guid>https://sickkids.technologypublisher.com/tech/Method_of_Treating_Medulloblastoma</guid></item><item><title>Slow release drug (FK506) delivery system for nerve regeneration in peripheral nerve surgery</title><caseId>RDLP 947</caseId><link>https://sickkids.technologypublisher.com/tech/Slow_release_drug_(FK506)_delivery_system_for_nerve_regeneration_in_peripheral_nerve_surgery</link><description>
	
		
			
			
			
			BACKGROUND

			There are many challenges to improving peripheral nerve regeneration and functional outcomes following injury. Peripheral nerve injuries can be severely debilitating, affecting otherwise healthy patients by permanently limiting their ability to perform activities of daily living. Currently, there are no therapeutic interventions available to aid in the recovery of damaged, severed/transected or crushed nerves beyond the traditional surgical procedures that offer limited outcomes. Systemically-administered FK506, a naturally occurring immunophilin that has be...</description><pubDate>Fri, 02 Jun 2023 13:09:51 GMT</pubDate><author>anny.song@sickkids.ca</author><guid>https://sickkids.technologypublisher.com/tech/Slow_release_drug_(FK506)_delivery_system_for_nerve_regeneration_in_peripheral_nerve_surgery</guid></item><item><title>Small Molecule CFTR potentiator as a therapy for Chronic Obstructive Pulmonary Disease (COPD)</title><caseId>RDLP 944</caseId><link>https://sickkids.technologypublisher.com/tech/Small_Molecule_CFTR_potentiator_as_a_therapy_for_Chronic_Obstructive_Pulmonary_Disease_(COPD)</link><description><![CDATA[
	
		
			
			
			
			BACKGROUND

			Chronic obstructive pulmonary disease (COPD) is induced by environmental toxins and severely compromises breathing. &nbsp;It is associated with chronic bronchitis with obstruction of the large and small airways leading to diminished airflow. &nbsp;Currently, treatments for COPD aim to manage symptoms through the use of bronchodilators to improve airflow and antibiotics to eradicate pulmonary infections. &nbsp;However, despite these interventions, the disease is progressive rendering patients vulnerable to severe outcomes after COVID-19 infection and exposure...]]></description><pubDate>Fri, 02 Jun 2023 13:09:43 GMT</pubDate><author>anny.song@sickkids.ca</author><guid>https://sickkids.technologypublisher.com/tech/Small_Molecule_CFTR_potentiator_as_a_therapy_for_Chronic_Obstructive_Pulmonary_Disease_(COPD)</guid></item><item><title>An ADHD digital therapeutic video game</title><caseId>RDLP 929</caseId><link>https://sickkids.technologypublisher.com/tech/An_ADHD_digital_therapeutic_video_game</link><description><![CDATA[
	
		
			
			&nbsp;

			BACKGROUND

			Attention Deficit Hyperactivity Disorder (ADHD) is a childhood onset clinical disorder of inattention, hyperactivity, and impulsivity (DSM-V). Behavioural hyperactivity in children with ADHD generally decreases with age, however, attentional, and inhibitory problems frequently continue into adulthood. Approximately 6.4 million American children are currently diagnosed with ADHD.&nbsp;
			
			Children with disorders that impact neurodevelopment (e.g., ADHD, autism) often have difficulties with executive functions and regulating emotions. Cognitive-based vi...]]></description><pubDate>Fri, 02 Jun 2023 13:09:23 GMT</pubDate><author>anny.song@sickkids.ca</author><guid>https://sickkids.technologypublisher.com/tech/An_ADHD_digital_therapeutic_video_game</guid></item><item><title>Novel coatings and topical applications that prevent and eliminate bacterial and fungal biofilms</title><caseId>RDLP 890</caseId><link>https://sickkids.technologypublisher.com/tech/Novel_coatings_and_topical_applications_that_prevent_and_eliminate_bacterial_and_fungal_biofilms</link><description><![CDATA[
	
		
			
			&nbsp;

			BACKGROUND

			Approximately 65-80% of all bacterial infections in humans are biofilm-related. Microbial biofilms, communities of adherent bacteria or fungi embedded in a matrix of exopolymeric substances (Figure 1), are a significant medical challenge as they are highly resistant to antimicrobial agents, disinfectants, and immune defenses. In fact, biofilm embedded microorganisms can tolerate antibiotic doses up to 1,000 times greater than doses that kill free-floating bacteria. Exopolysaccharides are a major component of the biofilm matrix, where they contribute to bi...]]></description><pubDate>Fri, 02 Jun 2023 13:08:37 GMT</pubDate><author>anny.song@sickkids.ca</author><guid>https://sickkids.technologypublisher.com/tech/Novel_coatings_and_topical_applications_that_prevent_and_eliminate_bacterial_and_fungal_biofilms</guid></item><item><title>Inhibitors of ILK:α-parvin as novel therapies for heart failure and cardiac fibrosis</title><caseId>RDLP 776</caseId><link>https://sickkids.technologypublisher.com/tech?title=Inhibitors_of_ILK%3a%ce%b1-parvin_as_novel_therapies_for_heart_failure_and_cardiac_fibrosis</link><description><![CDATA[
	
		
			
			&nbsp;

			BACKGROUND

			Heart failure is the single largest contributor to morbidity and mortality in the developed world. Only half of patients survive five years following their initial diagnosis, even when using the most advanced medical and surgical treatments. In developed countries, heart failure affects 1&ndash;2% of the adult population. Compared to other medical conditions, this disease burden results in the highest annual rate and cost per patient of hospitalization. The direct cost alone of heart failure is projected to increase to $51 billion by 2030 in the USA, with...]]></description><pubDate>Fri, 02 Jun 2023 13:06:09 GMT</pubDate><author>anny.song@sickkids.ca</author><guid>https://sickkids.technologypublisher.com/tech?title=Inhibitors_of_ILK%3a%ce%b1-parvin_as_novel_therapies_for_heart_failure_and_cardiac_fibrosis</guid></item></channel></rss>